Heat pipes are the specific class of heat exchangers. They are used in thermal management of electronic components. Research community is continuously working to obtain the optimum heat transfer performance. In present work, parametric study of heat pipe using nano- fluid has been carried out. The operating parameters of heat pipe like power supply, orientation (gravity assisted angle), filling- ratio, and nano-fluids concentration are being investigated to find the optimum thermal performance of heat pipe. Response surface method (RSM) is used to analyze the effect of operating parameters on thermal performance. The optimum value of thermal resistance and thermal efficiency are 0.3994 °C/Watt and 68.44% respectively. Most suitable power supply, inclination angle, filling ratio and nanofluid concentration are 185.85 W, 60.09°, 50.7% and 1.05 % respectively. The experimental results confirm and validate the RSM predicted results.