Our present investigation mainly focus on to identify the most appropriate refrigerants from various groups for replacing HFC-134a in a household refrigerator. The study involved conducting experiments using refrigerants from three different groups: Hydrofluoroolefin (HFO), Hydrofluorocarbon (HFC), and Hydrocarbon (HC). Among the tested refrigerants, R152a from the HFC group and HFC 1234yf from the HFO group showed the most potential. Compared to HFC-134a, both R152a and HFC 1234yf shows a reduction in refrigerating effect by approximately 4-7% and less power consumption in the compressor by around 5-7%.In conclusion, for replacing HFC-134a in a domestic refrigerator without needing alterations to the existing refrigeration system, two recommendable refrigerants are R152a and HFC 1234yf. These refrigerants are considered eco-friendly with zero ozone depletion potential (ODP) and low global warming potential (GWP) values.