The inlet and outlet size, number and location have a significant influence on the thermal environment indoor and air distribution for the temperature and velocity. In this work, numerical and experimental studies were performed to examine the influences of the inlet and outlet distribution, number and location, on the air movement and temperature distribution indoor. Also, the separation of the amount of the extracted air has been investigated in this study. To provide a comfortable environment for the occupants, important factors such as air temperature distribution, thermal sensation and draft rate should be evaluated carefully. Therefore, in this paper the occupant’s thermal sensation and the air movement and temperature distribution were used as the main evaluation index. In this investigation, three cases study were used tested. The experimental work was performed under the Iraqi weather conditions which are hot and dry in summer. The finding showed that the indoor thermal environments were significantly influenced by the opening locations of the exhaust. Also it was found that the satisfied human thermal comfort was obtained when the exhaust diffuser installed relatively far away from the supply diffuser. In addition, the best results were found by separate the amount of the exhaust air and extracted from the two exhausts opening. This will give the supplied air the ability to distribute inside room perfectly. Also, in order to prevent the air short circuit, the exhaust opening should not be located at the wall in front of the supply opening.