The current study is aimed to measure and analyze the impact of temperature (10°C < T < 90°C) and particle concentration (0.05% < ϕ < 1.5%) on thermo-physical properties of TiO2, ZnO and CuO nanoparticles suspended in Therminol-55. The nanoparticles were characterized by using various techniques, including TEM, XRD, FTIR, TGA/DSC. TEM images reveal that the morphology of TiO2 and ZnO as spherical nanoparticles whereas that of CuO is in the form of flakes. XRD pattern for TiO2, ZnO and CuO nanoparticles possess anatase, heaxagonal and monoclinic phase respectively. TGA results show that that TiO2 losses less mass than the ZnO and CuO nanoparticles at each stage of decomposition. Thereby making it more stable thermally as compared to the other samples. Two-step method has been employed to formulate stable Therminol-55 based nanofluids containing TiO2, ZnO and CuO nanoparticles for varying particle concentrations. Results show that the thermal conductivity of suspensions containing solid conducting particles increase with increasing nanoparticle content and temperature of dispersions in the fluid. The thermal conductivity of TiO2/Therminol-55, ZnO/Therminol-55 and CuO/Therminol-55 nanofluids increases up to 17.62%, 21.55% and 24.32% at particle concentration of 1.5 wt%. Further, the experimental results demonstrate that the density of nanofluids increased significantly with increase in concentration and decreased with temperature. Surface tension of nanofluids shows decrease with increase in particle concentration. This indicates that adding nanoparticles improve thermo-physical properties of nanofluid, making it suitable for use in heat pipe. The measured data for thermal conductivity and density are compared with existing theoretical models of nanofluids to check the effectivity of conventional models. A multi-variable new generalized correlations for thermal conductivity and density of Therminol-55 based nanofluids containing TiO2, ZnO and CuO nanoparticles are proposed.