In the modern world, with rapid inventions in microscale electronics, devices suffers undesirable internal heat generation and, due to their tiny shapes, undergo large heat flux conditions. This emphasizes the development of effective and efficient heat dissipation methods to boost their performance and keep them in safe working conditions. The jet impingement cooling method is used for cooling purposes in many engineering applications, and is popular for quick removal of heat from the solid surfaces. The present experimental study is an investigation of effect impingement of jet of water and ethylene glycol mixture over a heated surface. The blending of ethylene glycol (C2H6O2) with water (H2O) as a base fluid enhances the average (convective) heat transfer coefficient (HTC). The cooling fluid with different concentrations of C2H6O2 varying from 10%, 25%, 50%, and 100% shows higher values of average convective coefficient at similar flow conditions than pure water. The fluid having mixture proportions 50 % C2H6O2 and H2O shows an optimum value for heat transfer enhancement in the range of 30% to 75% than pure water at the same flow rates. It can be noted that based on mechanical stability and the cost associated, the experimental results reveal that the optimum value of the concentration of C2H6O2 in water is 50% for maximum heat transfer and at higher values of C2H6O2 hamper the mechanical stability and causes higher pumping power due to increase in viscosity of the fluid.