In hot and dry climates, evaporative cooling of the air by water spray can be applied in several requirements, such as evaporative condensers which the airflow is precooled by the water spray before it reaches the condenser. The interaction between water droplets and the air is a complicated two-phase flow that is affected by the several parameters. Here, an Eulerian-Lagrangian 3D model was developed to investigate the influence of important parameters on spray cooling performance in a rectangular duct. The evaluated parameters include the number of nozzles, inlet air flow rate, and spray water flow rate. The results represented that growth in the number of nozzles causes a reduction in the spray cooling efficiency. This is due to decrease of droplets retention time within the duct by increasing the number of nozzles at a constant total spray flow rate in the cases. The maximum and minimum spray cooling efficiency belong to the cases with one nozzle at water flow rate of 20 l/h and four nozzle at water flow rate of 5 l/h, respectively. The difference between spray cooling efficiency at 3 and 4 number of nozzles is less than 1.8%. Moreover, increasing the air flow rate from 0.5 l/h to 2 l/h (by 300%) makes a decrease in the spray cooling efficiency up to 58.6%.