Cement plants have the potential points to waste heat recovery . The method studied in this paper is based on the use of air quenching chamber (AQC) and suspension preheater (SP) Boilers which are installed at the output of the clean cooler and preheating stage respectively in Cement Plant. Due to the low temperature of the existed gases, three different fluids, water, R123 and R245fa are used as the working fluids and are evaluated in a similar cycle in terms of energy, exergy and the optimum parameters selection based on genetic algorithm. The results of this study showed that fluid R123 with optimized parameters leads to a 4% increase the total exergy loss and also will increase the production power from 5 MW to 9 MW. That is while in the case of water production power is increased from 4.8 to 5 MW is optimal state. Also the Results showed that the cost of produced electricity and exergy efficiency are lower in the case of organic fluid application in comparison with water as working fluid.