In the present contribution attention is focused to extend the application of multifluid descriptions to rarefied conditions for the first time . To this aim, a multifluid Maxwell model and a multifluid Smoluchowski model are proposed for near wall behavior of the constituents of a rarefied gas mixture. Afterwards, multifluid balance equations in conjunction with these boundary conditions are solved for some slip flows of binary gas mixtures between parallel plates T he co rresponding results are compared with those of a previously developed Navier Stokes solver. Inspection of the results indicates that while the Navier Stokes equations may lose their accuracy under high rarefaction, non equilibrium features are properly cap tured by developed multifluid description. This successful method is thereafter utilized to discuss the consequences of velocity slip, the tangential momentum accommodation coefficient, and mass disparity of the mixture constituents on the degree of non eq uilibrium between the constituents of the gas mixture s between parallel plates